ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

Base Information

Chemical Name:ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate
CAS No.:1644191-40-1
Molecular Formula:C₂₀H₃₁F₃O₂Si₂
Molecular Weight:416.631
Hs Code.:

Synonyms:ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

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Chemical Property of ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

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Technology Process of ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

There total 3 articles about ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1644191-23-0
((3-(trifluoromethyl)phenyl)methylene)bis(trimethylsilane)

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 1644191-40-1
ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

Guidance literature:: ((3-(trifluoromethyl)phenyl)methylene)bis(trimethylsilane); With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 1h; Schlenk technique; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -30 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

ethyl 2-bromomethyl-2-propenoate; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; hexane; at -30 - 25 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201402531

Reference yield:

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 1644191-40-1
ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -30 °C / Schlenk technique; Inert atmosphere

2.2: 0.25 h / -30 °C / Schlenk technique; Inert atmosphere

2.3: -30 - 25 °C / Schlenk technique; Inert atmosphere

With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; magnesium; lithium chloride; In tetrahydrofuran; hexane; ethylene dibromide; 1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531

Reference yield:

: 29955-12-2
bis(trimethylsilyl)methyl bromide

: 1644191-40-1
ethyl 2-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)benzyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -30 °C / Schlenk technique; Inert atmosphere

2.2: 0.25 h / -30 °C / Schlenk technique; Inert atmosphere

2.3: -30 - 25 °C / Schlenk technique; Inert atmosphere

With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; magnesium; lithium chloride; In tetrahydrofuran; hexane; ethylene dibromide; 1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531