Technology Process of (S)-2-[(R)-fluoro(phenyl)methyl]pyrrolidine
There total 7 articles about (S)-2-[(R)-fluoro(phenyl)methyl]pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / chloroform
2: lithium aluminium tetrahydride / tetrahydrofuran
3: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane
4: diethyl ether
5: diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere
6: hydrogenchloride / ethanol; water / 2.5 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; diethylamino-sulfur trifluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water;
DOI:10.1002/chem.201201316
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuryl dichloride
2: triethylamine / chloroform
3: lithium aluminium tetrahydride / tetrahydrofuran
4: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane
5: diethyl ether
6: diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere
7: hydrogenchloride / ethanol; water / 2.5 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; sulfuryl dichloride; oxalyl dichloride; diethylamino-sulfur trifluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water;
DOI:10.1002/chem.201201316
