(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Base Information

Chemical Name:(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol
CAS No.:861822-02-8
Molecular Formula:C₇₁H₁₁₂O₈Si₃
Molecular Weight:1177.92
Hs Code.:

(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Synonyms:(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Suppliers and Price of (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

There total 19 articles about (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 861822-09-5
(2R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-one

: 861822-02-8
(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran;
DOI:10.1021/ol050808u

Reference yield:

: 861821-96-7
(3S,4R,5S)-4,8-bis(tert-butyldimethylsilyloxy)-3,5-dimethyloct-1-yne

: 861822-02-8
(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 86 percent / n-butyllithium

2.1: 95 percent / (S,S)-Noyori catalyst / propan-2-ol

3.1: 100 percent / H₂ / Lindlar catalyst / toluene

4.1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5.1: 71 percent / HF*pyridine; pyridine / tetrahydrofuran / 21 h / 0 °C

6.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h

7.1: Ba(OH)2 / tetrahydrofuran / 0.5 h / 20 °C

7.2: 1.22 g / tetrahydrofuran; H₂O / 12 h

8.1: 65 percent / NaBH₄ / NiCl₂ / methanol; tetrahydrofuran; H₂O / 1 h / 0 °C

9.1: 95 percent / Li(t-BuO)3AlH / tetrahydrofuran / 30 h / 20 °C

With pyridine; 2,6-dimethylpyridine; barium dihydroxide; sodium tetrahydroborate; n-butyllithium; hydrogen; Dess-Martin periodane; pyridine hydrogenfluoride; lithium tri-t-butoxyaluminum hydride; Lindlar's catalyst; (S,S)-Noyori catalyst; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; 3.1: Lindlar hydrogenation / 6.1: Dess-Martin oxidation / 7.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm061385k

Reference yield:

: (3S,4R,5S)-1,1-Dibromo-4,8-bis-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-oct-1-ene

: 861822-02-8
(2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium

2.1: 86 percent / n-butyllithium

3.1: 95 percent / (S,S)-Noyori catalyst / propan-2-ol

4.1: 100 percent / H₂ / Lindlar catalyst / toluene

5.1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

6.1: 71 percent / HF*pyridine; pyridine / tetrahydrofuran / 21 h / 0 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h

8.1: Ba(OH)2 / tetrahydrofuran / 0.5 h / 20 °C

8.2: 1.22 g / tetrahydrofuran; H₂O / 12 h

9.1: 65 percent / NaBH₄ / NiCl₂ / methanol; tetrahydrofuran; H₂O / 1 h / 0 °C

10.1: 95 percent / Li(t-BuO)3AlH / tetrahydrofuran / 30 h / 20 °C

With pyridine; 2,6-dimethylpyridine; barium dihydroxide; sodium tetrahydroborate; n-butyllithium; hydrogen; Dess-Martin periodane; pyridine hydrogenfluoride; lithium tri-t-butoxyaluminum hydride; Lindlar's catalyst; (S,S)-Noyori catalyst; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; 4.1: Lindlar hydrogenation / 7.1: Dess-Martin oxidation / 8.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm061385k