(-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine

Base Information

• Chemical Name: (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine
• CAS No.: 142035-23-2
• Molecular Formula: C₂₀H₂₄N₂
• Molecular Weight: 292.424
• Mol file: 142035-23-2.mol

Synonyms:(-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine

Chemical Property of (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine

There total 21 articles about (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine (129912-34-1,132746-60-2,134731-58-1,135095-42-0,142035-22-1) → (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine (142035-23-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol (MeOH);

Reference yield: 89.0%

(2S,3S)-2-diphenylmethyl-N-((S)-1-phenylethyl)quinuclidin-3-amine → (-)-(2S,3S)-cis-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octane-3-amine (142035-23-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In isopropyl alcohol; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 49.5%

(-)-cis-2--1-azabicyclo<2.2.2>octan-3-amine (135007-74-8,135095-40-8,135095-41-9) → (-)-cis-2-(diphenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine (32531-19-4,32531-24-1,129912-96-5,141958-06-7,142035-23-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 7h; under 2068.6 Torr;

DOI:10.1021/jm00092a009

upstream raw materials:

(-)-cis-2--1-azabicyclo<2.2.2>octan-3-amine

cis-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine

3-keto-2-benzhydrylquinuclidine

2-(4,4'-Dibrombenzhydryl)-3-chinuclidinon

Downstream raw materials:

(-)-diphenylmethyl-3-((2-methoxy-5-aminophenyl)methylamino)-1-azabicyclo[3.2.2]octane

(2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octane-3-amine

(2S,3S)-N-[2-methoxy-5-(1-methoxy-1-methylethyl)-phenyl]methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine

(2S,3S)-N-[5-(1-hydroxy-1-methylethyl)-2-methoxy-phenyl]methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine