4-formylphenyl thiophene 3-carboxylate

Base Information

• Chemical Name: 4-formylphenyl thiophene 3-carboxylate
• CAS No.: 1396273-08-7
• Molecular Formula: C₁₂H₈O₃S
• Molecular Weight: 232.26
• Mol file: 1396273-08-7.mol

Synonyms:4-formylphenyl thiophene 3-carboxylate

Chemical Property of 4-formylphenyl thiophene 3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-formylphenyl thiophene 3-carboxylate

There total 3 articles about 4-formylphenyl thiophene 3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-thiophene carboxylic acid chloride (41507-35-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-formylphenyl thiophene 3-carboxylate (1396273-08-7)

Guidance literature:

With triethylamine; In butanone; at 0 ℃; for 4.5h;

DOI:10.1080/15421406.2013.858013

Reference yield: 62.0%

3-Thiophene carboxylic acid (88-13-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-formylphenyl thiophene 3-carboxylate (1396273-08-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/c2jm30550j

Reference yield:

3-Thiophene carboxylic acid (88-13-1) → 4-formylphenyl thiophene 3-carboxylate (1396273-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1 h / Reflux

2: triethylamine / butanone / 4.5 h / 0 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In butanone;

DOI:10.1080/15421406.2013.858013

upstream raw materials:

3-Thiophene carboxylic acid

4-hydroxy-benzaldehyde

3-thiophene carboxylic acid chloride

Downstream raw materials:

4-{(E)-[(4-decyloxyphenyl)imino]methyl}phenyl thiophene-3-carboxylate

4-{(E)-[(4-dodecyloxyphenyl)imino]methyl}phenyl thiophene-3-carboxylate

4-{(E)-[(4-tetradecyloxyphenyl)imino]methyl}phenyl thiophene-3-carboxylate

C₂₄H₂₅NO₃S