N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide

Base Information

• Chemical Name: N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide
• CAS No.: 1310012-73-7
• Molecular Formula: C₂₅H₄₅N₇O₂
• Molecular Weight: 475.678
• Mol file: 1310012-73-7.mol

Synonyms:N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide

Chemical Property of N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide

There total 9 articles about N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H51N7O2 → N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide (1310012-73-7)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; for 2h;

DOI:10.1016/j.bmcl.2011.02.079

Reference yield:

C44H68N6O8 → N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide (1310012-73-7)

Guidance literature:

Multi-step reaction with 4 steps

1: phosphoric acid / N,N-dimethyl-formamide

2: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1.5 h / 20 °C

3: Tris-amine resin / 0.5 h / 20 °C

4: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h

With ammonium cerium (IV) nitrate; phosphoric acid; sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.02.079

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → N-(1-((4-((3-aminopropyl)amino)butyl)amino)-1-oxo-4-phenylbutan-2-yl)-7-guanidinoheptanamide (1310012-73-7)

Guidance literature:

Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 0.33 h / 100 °C / Microwave irradiation

2: phosphoric acid / N,N-dimethyl-formamide

3: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1.5 h / 20 °C

4: Tris-amine resin / 0.5 h / 20 °C

5: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h

With ammonium cerium (IV) nitrate; phosphoric acid; sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 1: Ugi reaction;

DOI:10.1016/j.bmcl.2011.02.079

upstream raw materials:

3-phenyl-propionaldehyde

C₂₉H₄₄N₆O₂

C₁₈H₃₃N₃O₆

C₄₇H₆₁N₇O₄