3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

Base Information

Chemical Name:3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide
CAS No.:1415123-49-7
Molecular Formula:C₂₁H₁₈Cl₂N₄O₃
Molecular Weight:445.305
Hs Code.:

Synonyms:3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

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Chemical Property of 3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

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Technology Process of 3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

There total 8 articles about 3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1415125-37-9
2,6-dichloro-4-(methylcarbamoyl)benzoic acid

: 1415124-78-5
N-(2-methyl-1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide

: 1415123-49-7
3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

Guidance literature:: 2,6-dichloro-4-(methylcarbamoyl)benzoic acid; With thionyl chloride; In dichloromethane; at 100 ℃; for 3h;

N-(2-methyl-1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide; aluminum (III) chloride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1258298-04-2
2-amino-3,5-dichloro-4-(carbomethoxy)benzoic acid methyl ester

: 1415123-49-7
3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hypophosphorous acid; sodium nitrite; sulfuric acid / acetic acid / 19 h / -10 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.2: 0 - 20 °C

4.1: pyridine; lithium iodide / 3 h / Reflux

4.2: Cooling with ice

5.1: thionyl chloride / dichloromethane / 3 h / 100 °C

5.2: 20 °C

With pyridine; thionyl chloride; oxalyl dichloride; sulfuric acid; water; hypophosphorous acid; sodium hydroxide; lithium iodide; sodium nitrite; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetic acid;

Reference yield:

: 264272-64-2
2,6-dichlorobenzene-1,4-dicarboxylic acid,1-methyl ester

: 1415123-49-7
3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

1.2: 0 - 20 °C

2.1: pyridine; lithium iodide / 3 h / Reflux

2.2: Cooling with ice

3.1: thionyl chloride / dichloromethane / 3 h / 100 °C

3.2: 20 °C

With pyridine; thionyl chloride; oxalyl dichloride; lithium iodide; N,N-dimethyl-formamide; In dichloromethane;