(1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Base Information

• Chemical Name: (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid
• CAS No.: 1312919-80-4
• Molecular Formula: C₂₁H₂₇NO₅S
• Molecular Weight: 405.515
• Mol file: 1312919-80-4.mol

Synonyms:(1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Chemical Property of (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid

There total 3 articles about (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(1R,2R)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate (1312919-62-2) → (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid (1312919-80-4)

Guidance literature:

(1R,2R)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate; With sodium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=2; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

sodium 2-naphthol-6-sulfonate (135-76-2) → (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid (1312919-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / ethanol / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

3.2: pH 2 / Inert atmosphere

With sodium; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

C14H15ClO3S (857088-63-2) + trans-2-amino-1-cyclohexyl carboxylic acid ethyl ester (26849-62-7) → (1R,2R)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid (1312919-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

2.2: pH 2 / Inert atmosphere

With triethylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.011

upstream raw materials:

C₁₄H₁₅ClO₃S

trans-2-amino-1-cyclohexyl carboxylic acid ethyl ester

(1R,2R)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate

sodium 2-naphthol-6-sulfonate