C₂₁H₁₈FN₅OS

Base Information

Chemical Name:C₂₁H₁₈FN₅OS
CAS No.:1311387-78-6
Molecular Formula:C₂₁H₁₈FN₅OS
Molecular Weight:407.471
Hs Code.:

C<sub>21</sub>H<sub>18</sub>FN<sub>5</sub>OS

Synonyms:C₂₁H₁₈FN₅OS

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Chemical Property of C₂₁H₁₈FN₅OS

Chemical Property:

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Technology Process of C₂₁H₁₈FN₅OS

There total 9 articles about C₂₁H₁₈FN₅OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311388-12-1
C₂₆H₂₆FN₅O₃S

: 1311387-78-6
C₂₁H₁₈FN₅OS

Guidance literature:: With formic acid; at 40 ℃; for 1h;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1311387-78-6
C₂₁H₁₈FN₅OS

Guidance literature:: Multi-step reaction with 10 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 5 h / -78 °C

3.1: hydrogenchloride / methanol / 1.75 h / 20 °C

4.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

5.1: sulfuric acid / 1 h / Cooling with ice

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

7.1: potassium carbonate; water / tetrahydrofuran; methanol / 2.5 h

8.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 4 h / 60 °C

9.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.25 h / 20 °C

10.1: formic acid / 1 h / 40 °C

With hydrogenchloride; dmap; titanium(IV) tetraethanolate; formic acid; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; triethylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1311388-01-8
N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1311387-78-6
C₂₁H₁₈FN₅OS

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5 h / -78 °C

2.1: hydrogenchloride / methanol / 1.75 h / 20 °C

3.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: sulfuric acid / 1 h / Cooling with ice

5.1: dmap / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

6.1: potassium carbonate; water / tetrahydrofuran; methanol / 2.5 h

7.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 4 h / 60 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.25 h / 20 °C

9.1: formic acid / 1 h / 40 °C

With hydrogenchloride; dmap; formic acid; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; triethylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;