2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Chemical Name:2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide
CAS No.:1421848-19-2
Molecular Formula:C₃₁H₃₅FN₄O₂S
Molecular Weight:546.709
Hs Code.:

Synonyms:2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Chemical Property of 2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Technology Process of 2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

There total 8 articles about 2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.2%

: 130290-79-8
4-tetrahydropyranmethylamine

: 1421849-98-0
2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoic acid

: 1421848-19-2
2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1421848-19-2
2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 14 h / 100 °C

1.2: 3 h / 80 °C

2.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

4.1: ethanol / 16 h / 80 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

5.2: 4 h / 0 - 20 °C

6.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 20 - 60 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With Lawessons reagent; water; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 936084-44-5
ethyl 1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1421848-19-2
2-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-3-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

3.1: ethanol / 16 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

4.2: 4 h / 0 - 20 °C

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 20 - 60 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With Lawessons reagent; water; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;