9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one

Base Information

• Chemical Name: 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one
• CAS No.: 930572-03-5
• Molecular Formula: C₁₈H₁₅ClN₂O
• Molecular Weight: 310.783
• Mol file: 930572-03-5.mol

Synonyms:9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one

Chemical Property of 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one

Chemical Property:

Purity/Quality:

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Technology Process of 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one

There total 1 articles about 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

9-(2-Chloro-4-nitro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one (930572-47-7) → 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one (930572-03-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 20h;

DOI:10.1016/j.bmcl.2009.04.010

Reference yield: 71.0%

9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one (930572-03-5) + acetic anhydride (108-24-7) → N-[3-Chloro-4-(4-oxo-1,2,3,4-tetrahydro-carbazol-9-yl)-phenyl]-acetamide

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃; for 2h;

Reference yield: 63.0%

potassium cyanate (590-28-3) + 9-(4-Amino-2-chloro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one (930572-03-5) → 1-(3-chloro-4-(4-oxo-3,4-dihydro-1H-carbazol-9(2H)-yl)phenyl)urea

Guidance literature:

With acetic acid; In water; for 1h;

DOI:10.1016/j.bmcl.2009.04.010

upstream raw materials:

9-(2-Chloro-4-nitro-phenyl)-1,2,3,9-tetrahydro-carbazol-4-one