5-Benzyloxy-1H-indazole-3-carbaldehyde

Base Information

• Chemical Name: 5-Benzyloxy-1H-indazole-3-carbaldehyde
• CAS No.: 885271-28-3
• Molecular Formula: C15H12 N2 O2
• Molecular Weight: 252.27
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70693044
• Wikidata: Q82622067
• Mol file: 885271-28-3.mol

Synonyms:885271-28-3;5-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE;5-(Benzyloxy)-1H-indazole-3-carbaldehyde;DTXSID70693044;AKOS016013418;AB28671;5-phenylmethoxy-2H-indazole-3-carbaldehyde;FT-0721814;5-(BENZYLOXY)-2H-INDAZOLE-3-CARBALDEHYDE;A862126

Chemical Property of 5-Benzyloxy-1H-indazole-3-carbaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.707
• Boiling Point: 485.896°C at 760 mmHg
• Flash Point: 247.661°C
• PSA: 54.98000
• Density: 1.318g/cm³
• LogP: 2.95440
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 252.089877630
• Heavy Atom Count: 19
• Complexity: 305

Purity/Quality:

97% ^*data from raw suppliers

5-Benzyloxy-1H-indazole-3-carbaldehyde 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC3=C(NN=C3C=C2)C=O

Technology Process of 5-Benzyloxy-1H-indazole-3-carbaldehyde

There total 1 articles about 5-Benzyloxy-1H-indazole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-benzyloxy-1H-indole (1215-59-4) → 5-(benzyloxy)-1H-indazole-3-carbaldehyde (885271-28-3)

Guidance literature:

With hydrogenchloride; water; sodium nitrite; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c8ra01546e

Reference yield:

5-(benzyloxy)-1H-indazole-3-carbaldehyde (885271-28-3) + 4-(4-(piperidin-1-yl)piperidin-1-yl)benzene-1,2-diamine (882803-25-0) → 1'-{2-[5-(benzyloxy)-1H-indazol-3-yl]-1H-benzimidazol-5-yl}-1,4'-bipiperidine

Guidance literature:

5-(benzyloxy)-1H-indazole-3-carbaldehyde; 4-(4-(piperidin-1-yl)piperidin-1-yl)benzene-1,2-diamine; In ethanol; toluene; at 80 ℃;

With air; In ethanol; toluene; at 80 ℃;

DOI:10.1016/j.bmcl.2006.03.069

Reference yield:

5-(benzyloxy)-1H-indazole-3-carbaldehyde (885271-28-3) + 4-(4-(piperidin-1-yl)piperidin-1-yl)benzene-1,2-diamine (882803-25-0) → 2-(5-(benzyloxy)-1H-indazol-3-yl)-6-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazole (485834-04-6)

Guidance literature:

With air; In ethanol; toluene; Heating;

DOI:10.1016/j.bmcl.2006.04.043

upstream raw materials:

5-benzyloxy-1H-indole

Downstream raw materials:

2-(5-(benzyloxy)-1H-indazol-3-yl)-6-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazole