(+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal

Base Information

• Chemical Name: (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal
• CAS No.: 1300656-04-5
• Molecular Formula: C₂₀H₃₀O₃
• Molecular Weight: 318.456
• Mol file: 1300656-04-5.mol

Synonyms:(+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal

Chemical Property of (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal

There total 10 articles about (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C21H32O2 (1300656-03-4) → (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal (1300656-04-5)

Guidance literature:

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol; for 4h; Inert atmosphere;

DOI:10.1021/ja201467z

Reference yield: 81.0%

(+)-(2R,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-en-1-ol → (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal (1300656-04-5)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2014.11.061

Reference yield:

C28H38O5S → (+)-(2S,3R,6R,E)-3-(4-methoxybenzyloxy)-2,4,6-trimethylnon-4-enal (1300656-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium triethylborohydride / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

2: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 4 h / Inert atmosphere

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium triethylborohydride; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol;

DOI:10.1021/ja201467z

upstream raw materials:

C₁₆H₂₂O₄S

C₂₀H₃₀O₄S

C₂₁H₃₂O₂

(3S,4S)-4-hydroxy-3-methyl-1-hexene

Downstream raw materials:

C₄₉H₈₂O₉Si