2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Base Information

• Chemical Name: 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine
• CAS No.: 1542260-61-6
• Molecular Formula: C₃₈H₂₉N₅O₈
• Molecular Weight: 688.637

Synonyms:2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Chemical Property of 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

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Technology Process of 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

There total 7 articles about 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-acetate-α/β-2,3,5-tribenzoyl-2,3,4,5,5′-pentadeuterium-D-ribofuranoside + 6-benzoylamino-9-trimethylsilylpurine (60855-35-8) → 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-61-6)

Guidance literature:

6-benzoylamino-9-trimethylsilylpurine; With tin(IV) chloride; In 1,2-dichloro-ethane; at 40 ℃; for 0.25h;

1-O-acetate-α/β-2,3,5-tribenzoyl-2,3,4,5,5′-pentadeuterium-D-ribofuranoside; In 1,2-dichloro-ethane; for 2.5h; Reflux;

Reference yield:

1-O-acetate-α/β-2,3,5-tribenzoyl-2,3,4,5,5′-pentadeuterium-D-ribofuranoside + N-benzoyladenine (4005-49-6) → 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-61-6)

Guidance literature:

N-benzoyladenine; With N,O-bis-(trimethylsilyl)-acetamide; In 1,2-dichloro-ethane; for 15h; Reflux;

With tin(IV) chloride; In 1,2-dichloro-ethane; at 40 ℃; for 0.25h;

1-O-acetate-α/β-2,3,5-tribenzoyl-2,3,4,5,5′-pentadeuterium-D-ribofuranoside; In 1,2-dichloro-ethane; for 2.5h; Reflux;

Reference yield:

1-O-methyl-α/β-2,3,4,5,5′-pentadeuterium-D-ribofuranoside → 2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N6-benzoyladenosine (1542260-61-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 48 h / 0 - 4 °C

2.1: hydrogen bromide / acetic acid / 0.5 h / 20 °C

3.1: pyridine / chloroform / 72 h / 20 °C

4.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.25 h / 40 °C

4.2: 2.5 h / Reflux

With pyridine; hydrogen bromide; tin(IV) chloride; In dichloromethane; chloroform; acetic acid; 1,2-dichloro-ethane;

upstream raw materials:

methyl ribofuranoside

6-benzoylamino-9-trimethylsilylpurine

N-benzoyladenine

Downstream raw materials:

2′,3′,5′-trihydroxy-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁶-benzoyladenosine

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