Technology Process of (4bS,8aS,9S)-benzyl 2-((2-aminophenyl)amino)-3-(benzyloxy)-1-bromo-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
There total 10 articles about (4bS,8aS,9S)-benzyl 2-((2-aminophenyl)amino)-3-(benzyloxy)-1-bromo-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
Raney Ni;
In
methanol; water;
at 20 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C
2: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C
3: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C
4: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C
With
pyridinium hydrobromide perbromide; hydrazine hydrate; sodium t-butanolate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C
2: nitric acid; formic acid / water / 0 - 20 °C
3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C
6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C
7: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C
8: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C
With
formic acid; pyridinium hydrobromide perbromide; nitric acid; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
