2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

Base Information

Chemical Name:2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride
CAS No.:634903-72-3
Molecular Formula:C₂₆H₂₉N₃O₃S*ClH
Molecular Weight:500.062
Hs Code.:

Synonyms:2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

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Chemical Property of 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

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Technology Process of 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

There total 8 articles about 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate

: 634903-72-3
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide

: 634903-72-3
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane; water

2.1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 80 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol

4.1: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

4.2: 18 h / 20 °C

5.1: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide hydrochloride

: 634903-72-3
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl ethylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 80 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol

3.1: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); water;