6-BROMO-3-PHENYL-1H-INDAZOLE

Base Information

• Chemical Name: 6-BROMO-3-PHENYL-1H-INDAZOLE
• CAS No.: 885271-16-9
• Molecular Formula: C13H9 Br N2
• Molecular Weight: 273.132
• Hs Code.: 2933990090
• Mol file: 885271-16-9.mol

Synonyms:6-BROMO-3-PHENYL-1H-INDAZOLE

Chemical Property of 6-BROMO-3-PHENYL-1H-INDAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 3.99240
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-3-phenyl-1H-indazole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-3-PHENYL-1H-INDAZOLE

There total 3 articles about 6-BROMO-3-PHENYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(4-bromo-2-aminophenyl)phenyl-methanone (135776-98-6) → 6-bromo-3-phenyl-1H-indazole (885271-16-9)

Guidance literature:

(4-bromo-2-aminophenyl)phenyl-methanone; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.55h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃; for 1.16667h;

With sodium hydroxide; In water;

Reference yield:

N'-((4-bromophenyl)(phenyl)methylene)picolinohydrazide → 6-bromo-3-phenyl-1H-indazole (885271-16-9) + 3-(4-bromophenyl)-1H-indazole (1010691-04-9)

Guidance literature:

With potassium cyanate; oxygen; copper diacetate; In dimethyl sulfoxide; at 80 ℃; for 9h; Overall yield = 92 %; regioselective reaction;

DOI:10.1002/ejoc.201900947

Reference yield:

(4-bromophenyl)(phenyl)methanone (90-90-4) → 6-bromo-3-phenyl-1H-indazole (885271-16-9) + 3-(4-bromophenyl)-1H-indazole (1010691-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / ethanol / Reflux

2: copper diacetate; potassium cyanate; oxygen / dimethyl sulfoxide / 9 h / 80 °C

With potassium cyanate; oxygen; copper diacetate; trifluoroacetic acid; In ethanol; dimethyl sulfoxide;

DOI:10.1002/ejoc.201900947

upstream raw materials:

(4-bromo-2-aminophenyl)phenyl-methanone

(4-bromophenyl)(phenyl)methanone

Downstream raw materials:

phenyl(3-phenyl-1H-indazol-6-yl)methanol

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