2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

Base Information

Chemical Name:2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide
CAS No.:937177-70-3
Molecular Formula:C₂₈H₃₀N₂O₄
Molecular Weight:458.557
Hs Code.:

2-(4-hydroxy-2-phenyl-1<i>H</i>-indol-3-yl)-<i>N</i>-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

Synonyms:2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

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Chemical Property of 2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

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Technology Process of 2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

There total 5 articles about 2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 937177-66-7
2-(4-benzyloxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

: 937177-70-3
2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

Guidance literature:: With ammonium formate; palladium; In ethanol; water; ethyl acetate; at 70 ℃; for 0.166667h;
DOI:10.1016/j.bmcl.2007.01.054

Reference yield:

: 937177-45-2
N-[3-(4-hydroxy-phenyl)-1-methyl-propyl]-4-oxo-4-phenyl-butyramide

: 937177-70-3
2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HOAc; ZnCl₂ / 18 h / 70 °C

2.1: NaH / dimethylformamide / 0 °C

2.2: dimethylformamide / 2 h

3.1: 100 percent / NH₄CO₂H / Pd-black / ethanol; ethyl acetate; H₂O / 0.17 h / 70 °C

With ammonium formate; sodium hydride; acetic acid; zinc(II) chloride; palladium; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 1.1: Fischer indole synthesis;
DOI:10.1016/j.bmcl.2007.01.054

Reference yield:

: 4-(3-amino-butyl)-phenol; hydrochloride

: 937177-70-3
2-(4-hydroxy-2-phenyl-1H-indol-3-yl)-N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 63 percent / EDC; DMAP; N-methylmorpholine / CH₂Cl₂ / 3 h / 20 °C

2.1: HOAc; ZnCl₂ / 18 h / 70 °C

3.1: NaH / dimethylformamide / 0 °C

3.2: dimethylformamide / 2 h

4.1: 100 percent / NH₄CO₂H / Pd-black / ethanol; ethyl acetate; H₂O / 0.17 h / 70 °C

With 4-methyl-morpholine; dmap; ammonium formate; sodium hydride; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc(II) chloride; palladium; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 2.1: Fischer indole synthesis;
DOI:10.1016/j.bmcl.2007.01.054