(S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol

Base Information

• Chemical Name: (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol
• CAS No.: 1007401-48-0
• Molecular Formula: C₂₅H₃₈O₄Si
• Molecular Weight: 430.66
• Mol file: 1007401-48-0.mol

Synonyms:(S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol

Chemical Property of (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol

There total 4 articles about (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptyl pivalate (1007401-47-9) → (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol (1007401-48-0)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; at -60 ℃; for 2h;

DOI:10.3390/12020194

Reference yield:

(S)-7-(tert-butyldiphenylsilyloxy)heptane-1,3-diol (1007401-45-7) → (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol (1007401-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / pyridine / 0 - 20 °C

2: 82 percent / i-Pr₂NEt / 2 h / 0 - 20 °C

3: 100 percent / DIBAL-H / diethyl ether; hexane / 2 h / -60 °C

With pyridine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane;

DOI:10.3390/12020194

Reference yield:

(S)-7-(tert-butyldiphenylsilyloxy)-3-hydroxyheptyl pivalate (1007401-46-8) → (S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptan-1-ol (1007401-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / i-Pr₂NEt / 2 h / 0 - 20 °C

2: 100 percent / DIBAL-H / diethyl ether; hexane / 2 h / -60 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane;

DOI:10.3390/12020194

upstream raw materials:

(S)-7-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)heptyl pivalate

(S)-7-(tert-butyldiphenylsilyloxy)heptane-1,3-diol

(S)-7-(tert-butyldiphenylsilyloxy)-3-hydroxyheptyl pivalate

((2S,3S)-2-(4-(tert-butyldiphenylsilyloxy)butyl)oxiran-2-yl)methanol

Downstream raw materials:

(7S)-1-benzyloxy-11-(tert-butyldiphenylsilyloxy)-7-(methoxymethoxy)undec-3-yn-5-ol

(2R,4aS,5S,8aR)-1-benzyl-2-(2-benzyloxy)ethyl-4-(tert-butyldimethylsilyloxy)-5-methoxymethoxy-1,2,4a,5,6,7,8,8a-octahydroquinoline

(7S,E)-1-benzyloxy-11-(tert-butyldiphenylsilyloxy)-7-(methoxymethoxy)undec-3-en-5-ol

(S,6Z,8E)-11-benzyloxy-7-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)undeca-6,8-dienyl acetate