4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Base Information

Chemical Name:4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine
CAS No.:677729-73-6
Molecular Formula:C₂₂H₃₁NO₅
Molecular Weight:389.492
Hs Code.:

Synonyms:4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Suppliers and Price of 4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Chemical Property:

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Technology Process of 4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

There total 7 articles about 4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 677729-71-4
4-[(2E,5R,7S)-5,7-isopropylidenedioxy-1-oxo-9-phenyl-2-nonenyl]morpholine

: 677729-73-6
4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Guidance literature:: With triphenyl-arsane; 4 A molecular sieve; samarium(III) isopropoxide; tert.-butylhydroperoxide; (R)-1,1'-Bi-2-naphthol; In tetrahydrofuran; decane; at 20 ℃;
DOI:10.1002/chem.200305709

Reference yield:

: 4-[(2E,7S)-5,7-isopropylidenedioxy-1-oxo-9-phenyl-2-nonenyl]morpholine

: 677729-73-6
4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

: 4-[(2S,3R,5S,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Guidance literature:: With triphenyl-arsane; 4 A molecular sieve; samarium(III) isopropoxide; tert.-butylhydroperoxide; (R)-1,1'-Bi-2-naphthol; In tetrahydrofuran; decane; at 20 ℃; Title compound not separated from byproducts.;
DOI:10.1002/chem.200305709

Reference yield:

: 502690-42-8
ethyl (3R,5S)-3,5-isopropylidenedioxy-7-phenylheptanoate

: 677729-73-6
4-[(2S,3R,5R,7S)-2,3-epoxy-5,7-isopropylidenedioxy-1-oxo-9-phenylnonyl]morpholine

Guidance literature:: Multi-step reaction with 4 steps

1: 425 mg / LiBH₄; trimethoxyborane / diethyl ether / 1 h / 20 °C

2: 250 mg / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; TPAP / acetonitrile / 1 h / 20 °C

3: i-Pr₂NEt; LiCl / acetonitrile / 20 °C

4: 100 percent / Sm(OiPr)3; 4 Angstroem molecular sieves; AsPh₃ / (R)-BINOL; tert-butyl hydroperoxide / tetrahydrofuran; decane / 20 °C

With lithium borohydride; tetrapropylammonium perruthennate; Trimethyl borate; triphenyl-arsane; 4 A molecular sieve; samarium(III) isopropoxide; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; lithium chloride; tert.-butylhydroperoxide; (R)-1,1'-Bi-2-naphthol; In tetrahydrofuran; diethyl ether; decane; acetonitrile;
DOI:10.1002/chem.200305709