3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

Base Information

Chemical Name:3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one
CAS No.:1256779-57-3
Molecular Formula:C₃₆H₄₁N₅O₄
Molecular Weight:607.753
Hs Code.:

Synonyms:3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

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Chemical Property of 3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

There total 11 articles about 3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 1256780-01-4
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-N'-hydroxy-2-phenylacetoimidamide

: 530-62-1
1,1'-carbonyldiimidazole

: 1256779-57-3
3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256779-57-3
3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 12 h / Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

6.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

7.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

8.2: 4 h / 20 °C

9.1: trichlorophosphate / 2 h / 100 °C

10.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 90 °C

11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; phosphorus tribromide; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; n-heptane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256779-57-3
3-[[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydro pyrimidin-5-yl}methyl]-2,6-dipropylphenoxy](phenyl)methyl]-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 12 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

6.2: 4 h / 20 °C

7.1: trichlorophosphate / 2 h / 100 °C

8.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 90 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; n-heptane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;