3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

Base Information

Chemical Name:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide
CAS No.:1454656-37-1
Molecular Formula:C₁₈H₂₃N₅O
Molecular Weight:325.414
Hs Code.:

Synonyms:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

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Chemical Property of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

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Technology Process of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

There total 7 articles about 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1454657-35-2
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid

: 98-16-8
3-trifluoromethylaniline

: 121-44-8
triethylamine

: 1454656-20-2
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-[3-(trifluoromethyl)phenyl]benzamide

: 1454656-37-1
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 20h;

Reference yield:

: 618-89-3
methyl 3-bromobenzoate

: 1454656-37-1
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium diacetate; caesium carbonate; XPhos / tert-butyl alcohol; toluene / 16 h / 120 °C / Inert atmosphere; Sealed tube

2: toluene-4-sulfonic acid / water; acetone / 17 h / Reflux

3: 1,4-dioxane / 43 h / Reflux

4: sodium acetate trihydrate / ethanol / 15 h / Reflux

5: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

6: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 - 50 °C

With water; palladium diacetate; sodium acetate trihydrate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; sodium hydroxide; XPhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;

Reference yield:

: 658689-49-7
methyl-3-(4-oxopiperidin-1-yl)-benzoate

: 1454656-37-1
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 43 h / Reflux

2: sodium acetate trihydrate / ethanol / 15 h / Reflux

3: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 - 50 °C

With water; sodium acetate trihydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;