5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide
CAS No.:1378428-07-9
Molecular Formula:C₂₉H₂₇BF₂N₂O₆S
Molecular Weight:580.417
Hs Code.:

5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

Synonyms:5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

There total 4 articles about 5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378431-78-7
methyl 5-{[[5-cyclopropyl-3-[(ethylamino)carbonyl]-2-(4-fluorophenyl)-1-benzofuran-6-yl](methylsulfonyl)amino]methyl}-3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1378428-07-9
5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

Guidance literature:: methyl 5-{[[5-cyclopropyl-3-[(ethylamino)carbonyl]-2-(4-fluorophenyl)-1-benzofuran-6-yl](methylsulfonyl)amino]methyl}-3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; With lithium borohydride; In tetrahydrofuran; for 1h; Cooling with ice;

With water; In tetrahydrofuran;

Reference yield:

: 1378431-05-0
methyl 2-bromo-5-(bromomethyl)-3-fluorobenzoate

: 1378428-07-9
5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 1.5 h / 50 °C

2: potassium acetate; sodium bromide / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 22 h / 95 °C

3: lithium borohydride / tetrahydrofuran / 1 h / Cooling with ice

With lithium borohydride; potassium acetate; potassium carbonate; sodium bromide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 1378431-03-8
methyl 2-bromo-3-fluoro-5-methylbenzoate

: 1378428-07-9
5-cyclopropyl-N-ethyl-6-[[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux

2: potassium carbonate / acetonitrile / 1.5 h / 50 °C

3: potassium acetate; sodium bromide / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 22 h / 95 °C

4: lithium borohydride / tetrahydrofuran / 1 h / Cooling with ice

With N-Bromosuccinimide; lithium borohydride; potassium acetate; potassium carbonate; sodium bromide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; acetonitrile;