N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine

Base Information

Chemical Name:N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine
CAS No.:136727-15-6
Molecular Formula:C₂₀H₂₃N₃O
Molecular Weight:321.422
Hs Code.:
DSSTox Substance ID:DTXSID001187124

Synonyms:SCHEMBL9736388;DTXSID001187124;N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine;136727-15-6

Suppliers and Price of N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:321.184112366
Heavy Atom Count:24
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(CCCOC1=CC=C(C=C1)N)CC2=NC3=CC=CC=C3C=C2

Technology Process of N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine

There total 5 articles about N-[3-(4-Aminophenoxy)propyl]-N-methyl-2-quinolinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 136756-32-6
2-<methylamino>methyl>quinoline

: 136727-15-6
2-[N-[3-(4-Aminophenoxy)propyl]methylamino methyl]quinoline

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2585.7 Torr;
DOI:10.1021/jm00115a010

Reference yield:

: 79096-54-1
1-(3-Chloropropoxy)-4-nitrobenzene

: 136727-15-6
2-[N-[3-(4-Aminophenoxy)propyl]methylamino methyl]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / K₂CO₃, NaI / acetonitrile / 80 °C

2: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 2585.7 Torr

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In ethyl acetate; acetonitrile;
DOI:10.1021/jm00115a010

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 136727-15-6
2-[N-[3-(4-Aminophenoxy)propyl]methylamino methyl]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂O / 3.33 h / 10 - 20 °C

2: 36 percent / K₂CO₃, NaI / acetonitrile / 80 °C

3: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 2585.7 Torr

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In water; ethyl acetate; acetonitrile;
DOI:10.1021/jm00115a010