(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

Base Information

Chemical Name:(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol
CAS No.:1426696-01-6
Molecular Formula:C₂₁H₂₆ClFN₆O₂
Molecular Weight:448.928
Hs Code.:

Synonyms:(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

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Chemical Property of (2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

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Technology Process of (2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

There total 10 articles about (2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

: 1426696-01-6
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

: 1426701-37-2
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

Guidance literature:: With Phenomenex Lux C-4 column; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 1-[7-(3-azetidin-3-yl-5-chloro-4-fluoro-2-methoxyphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride

: 1426696-01-6
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

: 1426701-37-2
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 3 h / 90 °C

2: Phenomenex Lux C-4 column / ethanol; hexane / Resolution of racemate

With triethylamine; In ethanol; hexane;

Reference yield:

: 348-60-7
4-chloro-3-fluorophenol

: 1426696-01-6
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

: 1426701-37-2
(2S)-1-(3-[3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl]azetidin-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2 h / 60 °C / Inert atmosphere

1.2: 0.5 h / 180 °C

1.3: Cooling with ice

2.1: N-iodo-succinimide / acetic acid / 2 h / 70 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

4.2: 70 °C

5.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

6.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

7.2: 35 °C

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

9.1: triethylamine / ethanol / 3 h / 90 °C

10.1: Phenomenex Lux C-4 column / ethanol; hexane / Resolution of racemate

With hydrogenchloride; methanol; sodium tetrahydroborate; N-iodo-succinimide; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; potassium carbonate; ethylene dibromide; triethylamine; N,N-dimethyl-formamide; zinc; In 1,4-dioxane; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide;