(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

Base Information

Chemical Name:(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene
CAS No.:86534-19-2
Molecular Formula:C₂₆H₄₂N₂O₈
Molecular Weight:510.628
Hs Code.:

Synonyms:(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

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Chemical Property of (4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

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Technology Process of (4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

There total 5 articles about (4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 86545-48-4
(4aR,6S,6aS,22aS,22bR)-6-Methoxy-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene-10,19-dicarboxylic acid diethyl ester

: 86534-19-2
(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(01)91309-2

Reference yield:

: 4148-58-7
(4aR,6S,7S,8R,8aS)-6-Methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 86534-19-2
(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / n-Bu₄N⁺HSO₄^-, aq. NaOH (50percent) / benzene / 0.5 h / Ambient temperature

2: 90 percent / LiAlH₄ / diethyl ether / Heating

3: 85 percent / Et₃N / CHCl₃ / 0 °C

4: 60 percent / NaH, KBr / dimethylsulfoxide / 48 h / Ambient temperature

5: 90 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; potassium bromide; In tetrahydrofuran; diethyl ether; chloroform; dimethyl sulfoxide; benzene;
DOI:10.1039/c39830000132

Reference yield:

: 86534-16-9
2-[(4aR,6S,7S,8S,8aR)-7-(2-Hydroxy-ethoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-ethanol

: 86534-19-2
(4aR,6S,6aS,22aS,22bR)-6-Methoxy-10,19-dimethyl-2-phenyl-hexadecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Et₃N / CHCl₃ / 0 °C

2: 60 percent / NaH, KBr / dimethylsulfoxide / 48 h / Ambient temperature

3: 90 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; sodium hydride; triethylamine; potassium bromide; In tetrahydrofuran; chloroform; dimethyl sulfoxide;
DOI:10.1039/c39830000132