(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Base Information

Chemical Name:(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
CAS No.:1431530-93-6
Molecular Formula:C₄₃H₆₃N₃O₁₂
Molecular Weight:813.986
Hs Code.:

(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Synonyms:(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

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Chemical Property of (R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

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Technology Process of (R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

There total 14 articles about (R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 178446-02-1
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid

: 1431530-93-6
(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja401956b

Reference yield: 43.0%

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 195513-96-3
SLF

: 1431530-93-6
(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.0c00272

Reference yield:

: 215168-85-7
(1R)-1-[3-N-(tert-butyloxycarbonyl)aminophenyl]-3-(3,4-dimethoxyphenyl)-1-propanyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate

: 1431530-93-6
(R)-3-(3,4-dimethoxyphenyl)-1-(3-((2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yl)oxy)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl iodide / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 2 h / 25 °C / Inert atmosphere

With dmap; trimethylsilyl iodide; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1021/acsmedchemlett.0c00272