3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

Base Information

Chemical Name:3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate
CAS No.:1361574-84-6
Molecular Formula:C₂₉H₂₉N₇O₆S
Molecular Weight:603.659
Hs Code.:

Synonyms:3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

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Chemical Property of 3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

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Technology Process of 3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

There total 8 articles about 3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoic acid

: 91313-29-0
3-(4,6-diamino-1,3,5-triazin-2-ylamino)propan-1-ol

: 1361574-84-6
3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1361574-84-6
3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: [bis(acetoxy)iodo]benzene / 1.66 h / Inert atmosphere

2.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / N,N-dimethyl acetamide; water / 0.17 h / 100 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 18 h / 0 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(acetoxy)iodo]benzene; diisopropylamine; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 1361574-84-6
3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / tetrahydrofuran / 16 h / 25 °C

2.1: potassium hydroxide / water / 0.5 h / 100 °C

2.2: 1 h / 0 °C / pH 2

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / N,N-dimethyl acetamide; water / 0.17 h / 100 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 18 h / 0 °C / Inert atmosphere

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018