di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

Base Information

Chemical Name:di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate
CAS No.:1567347-32-3
Molecular Formula:C₃₃H₃₉ClF₂N₃O₇PS
Molecular Weight:726.178
Hs Code.:

Synonyms:di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

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Chemical Property of di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

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Technology Process of di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

There total 1 articles about di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1029872-54-5,918504-65-1
vemurafenib

: 1567347-31-2
di-tert-butyl 1-chloroethyl phosphate

: 1567347-32-3
di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

Guidance literature:: With potassium iodide; potassium hydroxide; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Inert atmosphere;

Reference yield: 74.0%

: 1567347-32-3
di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

: 1567347-33-4
1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl dihydrogen phosphate

Guidance literature:: With phosphoric acid; In ethyl acetate; at 20 ℃; for 0.0333333h;

Reference yield:

: 1567347-32-3
di-tert-butyl 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

: sodium 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphoric acid / ethyl acetate / 0.03 h / 20 °C

2: sodium hydroxide / ethyl acetate; water; tetrahydrofuran / 20 °C

With phosphoric acid; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;