Technology Process of 17-benzyl-3-methoxymorphinan-6-one
There total 6 articles about 17-benzyl-3-methoxymorphinan-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
17-benzyl-3-methoxymorphinan-6-spiro-2'-(1',3'-dioxolane);
With
hydrogenchloride;
In
water;
at 80 ℃;
for 1h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
water;
pH=9;
DOI:10.1016/j.bmc.2011.11.047
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C
2.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 4 h / Inert atmosphere; Reflux
3.1: water; potassium hydroxide / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere
5.2: pH 9
With
hydrogenchloride; platinum(IV) oxide; water; hydrogen; potassium carbonate; potassium hydroxide;
In
methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,1,2,2-tetrachloroethane;
DOI:10.1016/j.bmc.2011.11.047
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine; thionyl chloride / 0 - 20 °C / Inert atmosphere
2.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C
3.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 4 h / Inert atmosphere; Reflux
4.1: water; potassium hydroxide / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere
5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere
6.2: pH 9
With
pyridine; hydrogenchloride; platinum(IV) oxide; thionyl chloride; water; hydrogen; potassium carbonate; potassium hydroxide;
In
methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,1,2,2-tetrachloroethane;
DOI:10.1016/j.bmc.2011.11.047
