Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester
CAS No.:256648-00-7
Molecular Formula:C₂₂H₃₂O₃S
Molecular Weight:376.56
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

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Chemical Property of Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

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Technology Process of Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

There total 4 articles about Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 128386-57-2,106549-22-8
(R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl)propan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 256648-00-7
Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

Guidance literature:: With dmap; In dichloromethane; at 23 ℃;
DOI:10.1016/j.tet.2018.12.050

Reference yield:

: 85031-59-0,110715-68-9,126643-10-5
dihydroartemisinic acid

: 256648-00-7
Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / conc. HCl / overnight

2: 82 percent / LiAlH₄ / diethyl ether / 2.5 h / Heating

3: 73 percent / pyridine / CHCl₃ / 36 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; In diethyl ether; chloroform; 1: Esterification / 2: Reduction / 3: Tosylation;
DOI:10.1016/S0040-4020(99)00987-4

Reference yield:

: 87391-99-9
2-(4,7-dimethyl-(1α-H),2,3,(4β-H),(4aα-H),5,6,(8aα-H)-octahydronaphthalen-1-yl)propionic acid methyl ester

: 256648-00-7
Toluene-4-sulfonic acid (R)-2-((1R,4R,4aS,8aS)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / LiAlH₄ / diethyl ether / 2.5 h / Heating

2: 73 percent / pyridine / CHCl₃ / 36 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In diethyl ether; chloroform; 1: Reduction / 2: Tosylation;
DOI:10.1016/S0040-4020(99)00987-4