(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

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Chemical Name:(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester
CAS No.:219911-45-2
Molecular Formula:C₄₀H₄₅N₃O₁₁
Molecular Weight:743.811
Hs Code.:

(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

Synonyms:(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

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Chemical Property of (R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

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Technology Process of (R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

There total 2 articles about (R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 28252-50-8
N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH

: 174146-51-1
tert-butyl (R)-(3,5-dihydroxy-4-methoxyphenyl)glycine

: 219911-45-2
(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jo980880o

Reference yield:

: 728-87-0
4,4'-Dimethoxybenzhydrol

: 219911-45-2
(R)-((S)-2-Benzyloxycarbonylamino-3-{[bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-propionylamino)-(3,5-dihydroxy-4-methoxy-phenyl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / H₂SO₄, HOAc / 13.5 h / 25 °C

2: 92 percent / EDCI, HOBt / dimethylformamide

With sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jo980880o