(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Base Information

• Chemical Name: (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
• CAS No.: 1026518-06-8
• Molecular Formula: C₂₈H₃₅NO₈
• Molecular Weight: 513.588
• Mol file: 1026518-06-8.mol

Synonyms:(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Chemical Property of (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

There total 1 articles about (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester → (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (1026518-06-8) + (2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Guidance literature:

di-tert-butyl dicarbonate; (2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

chiral HPLC on Regis Whelk-O column;

DOI:10.1021/jm990171i

Reference yield:

(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (1026518-06-8) → (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester (246853-86-1)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1021/jm990171i

Reference yield:

(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (1026518-06-8) → trans,trans-(2R,3R,4S)-2-[4-(2-methoxyethoxy)phenyl]-4-(1,3-benzodioxol-5-yl)-1-(bis-o-tolylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / 1 h / 20 °C

2: N,N-diisopropylethylamine / acetonitrile / 20 °C

3: 6N aq. NaOH / ethanol / 20 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; acetonitrile; 1: acidolysis / 2: Alkylation / 3: Hydrolysis;

DOI:10.1021/jm990171i

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-[4-(2-methoxy-ethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester