cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one

Base Information

• Chemical Name: cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one
• CAS No.: 170751-03-8
• Molecular Formula: C₂₅H₃₀O₃
• Molecular Weight: 378.511

Synonyms:cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one

Chemical Property of cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one

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Technology Process of cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one

There total 1 articles about cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-tert-butylbenzene (3972-65-4) + 5'-Methoxyspiro(cyclohexane-1,2'-indan)-1',4-dione (56868-15-6) → cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one (170751-03-8) + trans-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one

Guidance literature:

With magnesium; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, refux, 1 h; 2.) THF, reflux, 1 h;

DOI:10.1002/hlca.19950780407

Reference yield: 98.0%

cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one (170751-03-8) → 4-<4-(tert-butyl)phenyl>-5'-methoxyspiroinden>-1'(3'H)-one (170751-05-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 130 ℃; for 0.166667h;

DOI:10.1002/hlca.19950780407

Reference yield: 30.0%

cis-4-<4-(tert-butyl)phenyl>-4-hydroxy-5'-methoxyspiroinden>-1'(3'H)-one (170751-03-8) → trans-4-<4-(tert-butyl)phenyl>-1',3'-dihydro-5'-methoxyspiroinden>-4-ol + 4-<4-(tert-butyl)phenyl>-1',3'-dihydro-5'-methoxyspiroindene>-1',4'-diol + trans-4-<4-(tert-butyl)phenyl>-1',3'-dihydro-5'-methoxyspiroindene> (170751-08-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 21 ℃; for 5h;

DOI:10.1002/hlca.19950780407

upstream raw materials:

1-bromo-4-tert-butylbenzene

5'-Methoxyspiro(cyclohexane-1,2'-indan)-1',4-dione

Downstream raw materials:

4-<4-(tert-butyl)phenyl>-5'-methoxyspiroinden>-1'(3'H)-one

trans-4-<4-(tert-butyl)phenyl>-1',3'-dihydro-5'-methoxyspiroindene>

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