(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1361293-48-2
Molecular Formula:C₃₀H₃₆Cl₂N₂O₆
Molecular Weight:591.532
Hs Code.:

(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Synonyms:(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 7 articles about (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1361293-55-1
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-2-((methoxymethoxy)methyl)-4-(trifluoromethylsulfonyloxy)-5,6-dihydropyridine-1(2H)-carboxylate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1361293-48-2
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1361293-50-6
(S)-3-Amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-hydroxybutanamide

: 1361293-48-2
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 50 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

4.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.2: 20 °C

6.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 1361293-51-7
(S)-methyl 3-(4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylamino)propanoate

: 1361293-48-2
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-hydroxyphenyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

3.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene;