3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

Base Information

Chemical Name:3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid
CAS No.:1300747-75-4
Molecular Formula:C₂₃H₂₁F₃N₄O₅
Molecular Weight:490.439
Hs Code.:

Synonyms:3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

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Chemical Property of 3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

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Technology Process of 3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

There total 5 articles about 3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300747-74-3
C₂₄H₂₃F₃N₄O₅

: 1300747-75-4
3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

Guidance literature:: C₂₄H₂₃F₃N₄O₅; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 1300747-64-1
methyl 3-methyl-2-(5-(4-nitrophenyl)oxazole-2-carboxamido)butanoate

: 1300747-75-4
3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

2.1: tetrahydrofuran / 16 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.2: pH 2

With iron; ammonium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 1300747-63-0
methyl 2-(5-(4-aminophenyl)oxazole-2-carboxamido)-3-methylbutanoate

: 1300747-75-4
3-methyl-2-(5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)oxazole-2-carboxamido)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

2.2: pH 2

With lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.ejmech.2012.05.016