1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione

Base Information

• Chemical Name: 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione
• CAS No.: 1040726-60-0
• Molecular Formula: C₂₄H₂₈N₂O₄
• Molecular Weight: 408.497

Synonyms:1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione

Chemical Property of 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione

Chemical Property:

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Technology Process of 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione

There total 2 articles about 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-benzylcarbamoyl-4-[(2-chloroacetyl)-((S)-1-phenylethyl)amino]butyl acetate (1040726-56-4) → 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione (1040726-60-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1002/jhet.5570450321

Reference yield:

4-oxobutyl acetate (6564-95-0) + Benzyl isocyanide (88333-03-3,10340-91-7) + (S)-1-phenyl-ethylamine (2627-86-3) + chloroacetic acid (79-11-8) → 1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione (1040726-60-0)

Guidance literature:

4-oxobutyl acetate; Benzyl isocyanide; (S)-1-phenyl-ethylamine; chloroacetic acid; In methanol; at 20 ℃; for 120h;

With caesium carbonate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2017.08.004

Reference yield: 99.0%

1-benzyl-3-(3-acetoxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione (1040726-60-0) → 1-benzyl-3-(3-hydroxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione (1040726-63-3)

Guidance literature:

With potassium hydroxide; In methanol; water; at 20 ℃; for 0.333333h; sonication;

DOI:10.1002/jhet.5570450321

upstream raw materials:

4-benzylcarbamoyl-4-[(2-chloroacetyl)-((S)-1-phenylethyl)amino]butyl acetate

4-oxobutyl acetate

Benzyl isocyanide

(S)-1-phenyl-ethylamine

Downstream raw materials:

1-benzyl-3-(3-hydroxypropyl)-4-((1'S)-1-phenylethyl)piperazine-2,5-dione

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