3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

Base Information

Chemical Name:3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene
CAS No.:1399860-74-2
Molecular Formula:C₂₉H₃₁NO₂
Molecular Weight:425.571
Hs Code.:

Synonyms:3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

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Chemical Property of 3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

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Technology Process of 3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

There total 3 articles about 3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1399860-62-8
3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

: 1399860-74-2
3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

Guidance literature:: With pyridine; trichlorophosphate; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.steroids.2012.05.003

Reference yield:

: 620-23-5
m-tolyl aldehyde

: 1399860-74-2
3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride

2: N-chloro-succinimide

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / Reflux

4: pyridine; trichlorophosphate / 24 h / 0 - 20 °C

With pyridine; N-chloro-succinimide; copper(l) iodide; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trichlorophosphate; In toluene;
DOI:10.1016/j.steroids.2012.05.003

Reference yield:

: 72-33-3
mestranol

: 61946-92-7
3-methyl-N-hydroxy-benzenecarboximidoyl chloride

: 1399860-74-2
3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / Reflux

2: pyridine; trichlorophosphate / 24 h / 0 - 20 °C

With pyridine; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trichlorophosphate; In toluene;
DOI:10.1016/j.steroids.2012.05.003