5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

Base Information

Chemical Name:5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine
CAS No.:169772-85-4
Molecular Formula:C₂₂H₂₁N₃S
Molecular Weight:359.495
Hs Code.:

Synonyms:5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

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Technology Process of 5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

There total 4 articles about 5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 169772-85-4
5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) NaOMe / 1.) MeOH, RT, 15 min, 2.) MeOH, a) 20 h RT, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 1.) conc. HCl, 2.) aq. KOH / 1.) acetone, reflux, 6 h

With hydrogenchloride; potassium hydroxide; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/0223-5234(96)88246-8

Reference yield:

: 137860-26-5
ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate

: 169772-85-4
5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOMe / 1.) MeOH, RT, 15 min, 2.) MeOH, a) 20 h RT, b) reflux, 3 h

2: 98 percent / POCl₃ / 6 h / 100 °C

3: 1.) conc. HCl, 2.) aq. KOH / 1.) acetone, reflux, 6 h

With hydrogenchloride; potassium hydroxide; sodium methylate; trichlorophosphate;
DOI:10.1016/0223-5234(96)88246-8

Reference yield:

: 135689-67-7
5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidin-4(3H)-one

: 169772-85-4
5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / POCl₃ / 6 h / 100 °C

2: 1.) conc. HCl, 2.) aq. KOH / 1.) acetone, reflux, 6 h

With hydrogenchloride; potassium hydroxide; trichlorophosphate;
DOI:10.1016/0223-5234(96)88246-8