N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

Base Information

Chemical Name:N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide
CAS No.:167103-01-7
Molecular Formula:C₁₅H₂₀INO₃S
Molecular Weight:421.299
Hs Code.:

Synonyms:N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

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Chemical Property of N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

There total 5 articles about N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 167102-95-6
N-(2-iodophenyl)-N-[2-(oxoethyl)cyclohex-2-enyl]methanesulfonamide

: 167103-01-7
N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.0833333h;
DOI:10.1021/jo990891x

Reference yield:

: 615-43-0
2-iodophenylamine

: 167103-01-7
N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / 4-(dimethylamino)pyridine; pyridine / 12 h / Heating

2: 67 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3: 86 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 16 h / 20 °C

4: 96 percent / sodium periodate / diethyl ether; ethanol; H₂O / 5 h / 20 °C

5: 86 percent / NaBH₄ / methanol / 0.08 h

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; tert-butyl alcohol; 1: Acylation / 2: Alkylation / 3: Oxidation / 4: Oxidation / 5: Reduction;
DOI:10.1021/jo990891x

Reference yield:

: 116547-92-3
N-(2-iodophenyl)methanesulfonamide

: 167103-01-7
N-[2-(2-hydroxyethyl)-2-cyclohexen-1-yl]-N-(2-iodophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

2: 86 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 16 h / 20 °C

3: 96 percent / sodium periodate / diethyl ether; ethanol; H₂O / 5 h / 20 °C

4: 86 percent / NaBH₄ / methanol / 0.08 h

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; tert-butyl alcohol; 1: Alkylation / 2: Oxidation / 3: Oxidation / 4: Reduction;
DOI:10.1021/jo990891x