2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Base Information

Chemical Name:2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine
CAS No.:126616-57-7
Molecular Formula:C₂₄H₂₆IN₅O₃
Molecular Weight:559.407
Hs Code.:

Synonyms:2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Suppliers and Price of 2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

There total 7 articles about 2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 126616-56-6
2',3'-isopropylidene-5'-(5-hydroxy-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

: 126616-57-7
2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Guidance literature:: With methyltriphenoxyphosphonium iodide; In dichloromethane; 1. -78 deg C -> room temp. , 30 min 2. 2 h at room temp.;
DOI:10.1021/jo00297a034

Reference yield:

: 126616-46-4
N⁶-benzoyl-2',3'-isopropylidene-5'-(2-hydroxytetrahydrofuran-3-yl)-5'-deoxyadenosine

: 126616-57-7
2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Guidance literature:: Multi-step reaction with 6 steps

1: 39 percent / imidazole / dimethylformamide; hexamethylphosphoric acid triamide / 1.33 h / 50 °C

2: 31 percent / potassium tert-butoxide / tetrahydrofuran / -78 °C / a) 15 min b) 5 h

3: 78 percent / CuI, Et₃N / PdCl₂(PPh₃)2 / a) 50 deg C, 3 h b) room temp., overnight

4: 94 percent / NH₄OH / methanol / 18 h / Ambient temperature

5: 97 percent / HOAc, tetrabutylammonium fluoride / tetrahydrofuran / 8.67 h / Ambient temperature

6: 86 percent / methyltriphenoxyphosphonium iodide / CH₂Cl₂ / 1. -78 deg C -> room temp. , 30 min 2. 2 h at room temp.

With 1H-imidazole; ammonium hydroxide; copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00297a034

Reference yield:

: 85681-04-5
N⁶-Benzoyl-2',3'-O-isopropylidene-5'-C-(2-oxotetrahydro-3-furanyl)-5'-deoxyadenosine

: 126616-57-7
2',3'-isopropylidene-5'-(5-iodo-1-phenyl-1-pentyn-3-yl)-5'-deoxyadenosine

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / DIBAL / tetrahydrofuran; toluene / 3 h / -78 °C

2: 39 percent / imidazole / dimethylformamide; hexamethylphosphoric acid triamide / 1.33 h / 50 °C

3: 31 percent / potassium tert-butoxide / tetrahydrofuran / -78 °C / a) 15 min b) 5 h

4: 78 percent / CuI, Et₃N / PdCl₂(PPh₃)2 / a) 50 deg C, 3 h b) room temp., overnight

5: 94 percent / NH₄OH / methanol / 18 h / Ambient temperature

6: 97 percent / HOAc, tetrabutylammonium fluoride / tetrahydrofuran / 8.67 h / Ambient temperature

7: 86 percent / methyltriphenoxyphosphonium iodide / CH₂Cl₂ / 1. -78 deg C -> room temp. , 30 min 2. 2 h at room temp.

With 1H-imidazole; ammonium hydroxide; copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; methyltriphenoxyphosphonium iodide; diisobutylaluminium hydride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00297a034