1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

Base Information

Chemical Name:1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea
CAS No.:1242163-58-1
Molecular Formula:C₁₈H₁₈BrN₅O₄S₂
Molecular Weight:512.408
Hs Code.:

Synonyms:1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

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Chemical Property of 1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

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Technology Process of 1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

There total 6 articles about 1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.7%

: 590-28-3
potassium cyanate

: 1369393-88-3
C₁₇H₁₇BrN₄O₃S₂

: 1242163-58-1
1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

Guidance literature:: With acetic acid; In methanol; water; at 30 ℃; for 4h;
DOI:10.1039/c3ob41936c

Reference yield:

: 1579939-08-4
C₁₇H₁₅BrN₄O₃S₂

: 1242163-58-1
1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium cyanoborohydride; methyl orange / methanol; tetrahydrofuran / 0.08 h / 30 °C

1.2: 4 h / 30 °C

2.1: acetic acid / water; methanol / 4 h / 30 °C

With methyl orange; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1039/c3ob41936c

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 1242163-58-1
1-(2-(1-(4-bromophenyl)-5-(4-(methylsulfonyl)phenyl)-1H-1,2,4-triazol-3-ylthio)ethyl)-1-hydroxyurea

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water; ethanol / 5 h / Reflux

2.1: triethylamine / acetone / 2 h / Reflux

3.1: sodium hydroxide / methanol / 2 h / Reflux

4.1: potassium carbonate / acetone / 0.5 h / 50 °C

4.2: 3 h / Reflux

5.1: sodium cyanoborohydride; methyl orange / methanol; tetrahydrofuran / 0.08 h / 30 °C

5.2: 4 h / 30 °C

6.1: acetic acid / water; methanol / 4 h / 30 °C

With hydrogenchloride; methyl orange; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetone;
DOI:10.1039/c3ob41936c