N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide

Base Information

• Chemical Name: N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide
• CAS No.: 235099-75-9
• Molecular Formula: C₁₉H₂₁N₃O₂S
• Molecular Weight: 355.461
• Mol file: 235099-75-9.mol

Synonyms:N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide

Chemical Property of N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide

There total 4 articles about N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-Tetrahydro-2-naphthol (1125-78-6) → N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide (235099-75-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH

2: H₂SO₄ / 6 h / Heating

3: hydrazine hydrate / ethanol / 2 h / Heating

4: ethanol / 1 h / Heating

With sodium hydroxide; sulfuric acid; hydrazine hydrate; In ethanol; 1: Alkylation / 2: Esterification / 3: Substitution / 4: Addition;

DOI:10.1016/S0014-827X(99)00016-6

Reference yield:

ethyl 2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetate (868598-94-1) → N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide (235099-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / Heating

2: ethanol / 1 h / Heating

With hydrazine hydrate; In ethanol; 1: Substitution / 2: Addition;

DOI:10.1016/S0014-827X(99)00016-6

Reference yield:

2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetic acid (1878-59-7) → N-phenyl-2-[2-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)acetyl]hydrazine carbothioamide (235099-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / 6 h / Heating

2: hydrazine hydrate / ethanol / 2 h / Heating

3: ethanol / 1 h / Heating

With sulfuric acid; hydrazine hydrate; In ethanol; 1: Esterification / 2: Substitution / 3: Addition;

DOI:10.1016/S0014-827X(99)00016-6

upstream raw materials:

phenyl isothiocyanate

ethyl 2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide

5,6,7,8-Tetrahydro-2-naphthol

2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetic acid

Downstream raw materials:

3-[(5,6,7,8-Tetrahydronaphthalen-2-yl)oxymethyl]-4-phenyl-5-mercapto-1,2,4-triazole