1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

Base Information

Chemical Name:1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one
CAS No.:85732-28-1
Molecular Formula:C₂₀H₁₈Cl₂N₂O₃
Molecular Weight:405.281
Hs Code.:

Synonyms:1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

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Chemical Property of 1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

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Technology Process of 1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

There total 9 articles about 1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 85732-39-4
6-chlorospiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one*HCl

: 536-38-9
4-chlorobenzoylmethyl bromide

: 85732-28-1
1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: With TEA; In ethanol; Ambient temperature;
DOI:10.1248/cpb.33.1129

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 85732-28-1
1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C

2: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating

3: pyridine / 0 °C

4: aq. NaOH / methanol

5: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature

6: 84.9 percent / 3.52 N HCl (in ethyl acetate) / CH₂Cl₂ / 1.5 h / Ambient temperature

7: 85.5 percent / TEA / ethanol / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; TEA; sulfuric acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1248/cpb.33.1129

Reference yield:

: 65854-91-3
N-(4-chlorophenyl)-2,2-dimethylpropionamide

: 85732-28-1
1'-(4-chlorobenzoylmethyl)-6-chlorospiro<4H-3,1-bezoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C

2: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating

3: pyridine / 0 °C

4: aq. NaOH / methanol

5: 85.4 percent / diethyl ether; 1,2-dichloro-ethane / 1 h / Ambient temperature

6: 84.9 percent / 3.52 N HCl (in ethyl acetate) / CH₂Cl₂ / 1.5 h / Ambient temperature

7: 85.5 percent / TEA / ethanol / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; TEA; sulfuric acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1248/cpb.33.1129