Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

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Chemical Name:Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester
CAS No.:582315-02-4
Molecular Formula:C₄₃H₄₇F₃N₆O₆S₂
Molecular Weight:865.01
Hs Code.:

Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

Synonyms:Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

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Technology Process of Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

There total 19 articles about Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5516-85-8
1,8,1'-trimethyl-2,3,8,8aR,2',3',8',8'aR-octahydro-1H-1'H-[3aS,3'aS]bipyrrolo[2,3-b]indole

: 582315-02-4
Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 74 percent / NaHMDS / tetrahydrofuran / -78 °C

2.1: s-BuLi; TMEDA / diethyl ether; pentane / 0.75 h / -78 °C

2.2: 90 percent / diiodoethane / diethyl ether; pentane / -78 - 20 °C

3.1: 94 percent / TMSOTf; H₂O / CH₂Cl₂ / 0.17 h / 20 °C

4.1: Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

4.2: 0.162 g / P(2-furyl)3; NMP; CuI / Pd₂(dba)3*CHCl₃ / 36 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; water; sec.-butyllithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; pentane; 4.2: Stille coupling;
DOI:10.1016/S0040-4020(03)00855-X

Reference yield:

: 582315-03-5
1,8,1'-trimethyl-1,2,3,8aR,2',3',8',8'aR-octahydro-1'H-[3aS,3'aS]bi[pyrrolo[2,3-b]indolyl]-8-carboxylic acid tert-butyl ester

: 582315-02-4
Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: s-BuLi; TMEDA / diethyl ether; pentane / 0.75 h / -78 °C

1.2: 90 percent / diiodoethane / diethyl ether; pentane / -78 - 20 °C

2.1: 94 percent / TMSOTf; H₂O / CH₂Cl₂ / 0.17 h / 20 °C

3.1: Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

3.2: 0.162 g / P(2-furyl)3; NMP; CuI / Pd₂(dba)3*CHCl₃ / 36 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; water; sec.-butyllithium; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; pentane; 3.2: Stille coupling;
DOI:10.1016/S0040-4020(03)00855-X

Reference yield:

: 582315-12-6
7-iodo-1,1',8'-trimethyl-1,2,3,8a,2',3',8',8'a-octahydro-1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-8-carboxylic acid tert-butyl ester

: 582315-02-4
Trifluoro-methanesulfonic acid 2-{methyl-[(Z)-4-[methyl-(toluene-4-sulfonyl)-amino]-2-((3aS,8aS,3'aS,8'aR)-1,1',8'-trimethyl-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]-7-yl)-but-2-enoyl]-amino}-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / TMSOTf; H₂O / CH₂Cl₂ / 0.17 h / 20 °C

2.1: Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 0 °C

2.2: 0.162 g / P(2-furyl)3; NMP; CuI / Pd₂(dba)3*CHCl₃ / 36 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; water; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 2.2: Stille coupling;
DOI:10.1016/S0040-4020(03)00855-X