tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

Base Information

Chemical Name:tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate
CAS No.:293733-52-5
Molecular Formula:C₉H₁₃BrN₂O₂
Molecular Weight:261.118
Hs Code.:
DSSTox Substance ID:DTXSID701182206
Nikkaji Number:J1.368.000K

Synonyms:tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate;293733-52-5;SCHEMBL19356999;DTXSID701182206;1,1-Dimethylethyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

Suppliers and Price of tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:260.01604
Heavy Atom Count:14
Complexity:227

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1=CN=C(N1C)Br

Technology Process of tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

There total 1 articles about tert-Butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41806-40-0
1-methyl-1H-imidazole-5-carboxylic acid

: 293733-52-5
tert-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / p-TsCl; pyridine / 20 °C

2: 92 percent / NBS; AIBN / CCl₄ / 60 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); p-toluenesulfonyl chloride; In tetrachloromethane; 1: Esterification / 2: Bromination;

Reference yield: 79.0%

: 103-71-9
phenyl isocyanate

: 293733-52-5
tert-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

: t-butyl 1-methyl-2-phenylcarbamoyl-1H-imidazole-5-carboxylate

Guidance literature:: tert-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

phenyl isocyanate; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 77.0%

: 552-89-6
2-nitro-benzaldehyde

: 293733-52-5
tert-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate

: t-butyl 2-[1'-(2''nitrophenyl)hydroxymethyl]-1-methyl-1H-imidazole-5-carboxylate

Guidance literature:: tert-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

2-nitro-benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃;