methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate

Base Information

• Chemical Name: methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate
• CAS No.: 42443-25-4
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.312
• Mol file: 42443-25-4.mol

Synonyms:methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate

Chemical Property of methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate

There total 8 articles about methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl (E)-2-(4-methoxyphenyl)-3-(p-toluenesulfonyloxy)prop-2-enoate (1188274-66-9) + phenylboronic acid (98-80-6) → methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate (42443-25-4)

Guidance literature:

With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 150 - 155 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol9013359

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid (30292-50-3) → C17H18O3 + C17H18O3 + C17H17ClO3 + C17H17ClO3 + methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate (42443-25-4)

Guidance literature:

(E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid; With palladium/alumina; hydrogen; cinchonidine; In water; N,N-dimethyl-formamide; at 21.84 ℃; for 6h; under 750.075 Torr;

diazomethane; In diethyl ether; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.molcata.2010.09.013

Reference yield:

(2S,3R)-2,3-Dibromo-2-(4-methoxy-phenyl)-3-phenyl-propionic acid methyl ester → methyl (E)-2-(4-methoxyphenyl)-3-phenylprop-2-enoate (42443-25-4)

Guidance literature:

With triethylamine hydrochloride; triethylamine; In methanol; at 30 ℃; Rate constant;

DOI:10.1039/a706372e

upstream raw materials:

methyl (E)-2-(4-methoxyphenyl)-3-(p-toluenesulfonyloxy)prop-2-enoate

phenylboronic acid

diazomethane

(E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid