2-CLOROPYRIDINE-4-METHYLACETATE

Base Information

• Chemical Name: 2-CLOROPYRIDINE-4-METHYLACETATE
• CAS No.: 884600-82-2
• Molecular Formula: C8H8 Cl N O2
• Molecular Weight: 185.61
• Mol file: 884600-82-2.mol

Synonyms:2-CLOROPYRIDINE-4-METHYLACETATE

Chemical Property of 2-CLOROPYRIDINE-4-METHYLACETATE

Chemical Property:

• PSA: 39.19000
• LogP: 1.45050

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl2-(2-Chloropyridin-4-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-(2-Chloropyridin-4-yl)acetate is an intermediate used to prepare piperidines and related compounds for treatment of Alzheimer''s disease.

Technology Process of 2-CLOROPYRIDINE-4-METHYLACETATE

There total 2 articles about 2-CLOROPYRIDINE-4-METHYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-chloro-4-picoline (3678-62-4) + carbonic acid dimethyl ester (616-38-6) → 2-chloro-4-methoxycarbonylmethylpyridine (884600-82-2)

Guidance literature:

2-chloro-4-picoline; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -70 ℃; for 1h;

carbonic acid dimethyl ester; In tetrahydrofuran; n-heptane; ethylbenzene; at -40 - 0 ℃; for 1.5h;

With ammonium chloride; In tetrahydrofuran; n-heptane; ethylbenzene; water;

Reference yield: 53.0%

2-chloro-4-picoline (3678-62-4) + methyl chloroformate (79-22-1) → 2-chloro-4-methoxycarbonylmethylpyridine (884600-82-2)

Guidance literature:

2-chloro-4-picoline; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1.83333h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.83333h;

DOI:10.1016/j.bmcl.2010.02.040

Reference yield: 75.0%

2-chloro-4-methoxycarbonylmethylpyridine (884600-82-2) + 4-trifluoromethylphenylboronic acid (128796-39-4) → methyl (2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl)acetate (884600-83-3)

Guidance literature:

With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; toluene; for 16h; Heating / reflux;

upstream raw materials:

2-chloro-4-picoline

methyl chloroformate

carbonic acid dimethyl ester

Downstream raw materials:

methyl (2-{[4-(trifluoromethyl)phenyl]ethynyl}pyridin-4-yl)acetate

methyl (2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl)acetate

methyl{2-[4-(trifluoromethyl)benzyl]pyridin-4-yl}acetate