1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

• Chemical Name: 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
• CAS No.: 114185-18-1
• Molecular Formula: C₂₆H₂₈ClNO₅*ClH
• Molecular Weight: 506.426

Synonyms:1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property of 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

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Technology Process of 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 3 articles about 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline (114185-13-6) → 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (114185-18-1)

Guidance literature:

With hydrogenchloride; In methanol; for 24h; Heating;

DOI:10.1021/jm00403a006

Reference yield:

1-(3,4,5-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline (102921-08-4) → 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (114185-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bicarbonate, sodium iodide / ethanol / 4 h / Heating

2: 73 percent / conc. HCl / methanol / 24 h / Heating

With hydrogenchloride; sodium hydrogencarbonate; sodium iodide; In methanol; ethanol;

DOI:10.1021/jm00403a006

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) → 1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (114185-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bicarbonate, sodium iodide / ethanol / 4 h / Heating

2: 73 percent / conc. HCl / methanol / 24 h / Heating

With hydrogenchloride; sodium hydrogencarbonate; sodium iodide; In methanol; ethanol;

DOI:10.1021/jm00403a006

upstream raw materials:

1-(3,4,5-trimethoxybenzyl)-2-(4-chlorobenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

1-(3,4,5-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

1-Chloro-4-(chloromethyl)benzene

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