C₂₀H₂₅BrO₄

Base Information

• Chemical Name: C₂₀H₂₅BrO₄
• CAS No.: 441352-72-3
• Molecular Formula: C₂₀H₂₅BrO₄
• Molecular Weight: 409.32
• Mol file: 441352-72-3.mol

Synonyms:C₂₀H₂₅BrO₄

Chemical Property of C₂₀H₂₅BrO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₅BrO₄

There total 10 articles about C₂₀H₂₅BrO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-epoxy-1,4,4a,6,7,8a-hexahydro-1,4-methano-naphthalene-5,8-dione (2435-32-7,15052-12-7) → C20H25BrO4 (441352-72-3)

Guidance literature:

Multi-step reaction with 10 steps

1: 80 percent / NaOH / 3 h / 20 °C

2: 77 percent / diisobutylaluminum hydride / CH₂Cl₂ / 0.5 h / -78 °C

3: lipase LIP / diethyl ether / 3.5 h / 30 °C

4: 78 percent / K₂CO₃; MeOH / 35 h / 20 °C

5: 100 percent / MnO₂ / CH₂Cl₂ / 20 °C

6: 80 percent / NaOH / Bu₄NHSO₄ / benzene

7: H₂O₂; NaOH / methanol / 20 °C

8: LiAlH₄ / dioxane / Heating

9: 86 percent / NBS / CH₂Cl₂ / 20 °C

With methanol; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; lipase LIP; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0040-4039(02)00750-5

Reference yield:

ethyl 5-oxo-tricyclo[5.2.1.0.]deca-3,8-diene-2-carboxylate (121312-57-0) → C20H25BrO4 (441352-72-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 77 percent / diisobutylaluminum hydride / CH₂Cl₂ / 0.5 h / -78 °C

2: lipase LIP / diethyl ether / 3.5 h / 30 °C

3: 78 percent / K₂CO₃; MeOH / 35 h / 20 °C

4: 100 percent / MnO₂ / CH₂Cl₂ / 20 °C

5: 80 percent / NaOH / Bu₄NHSO₄ / benzene

6: H₂O₂; NaOH / methanol / 20 °C

7: LiAlH₄ / dioxane / Heating

8: 86 percent / NBS / CH₂Cl₂ / 20 °C

With methanol; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; lipase LIP; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0040-4039(02)00750-5

Reference yield:

(1R,3aS,4S,7R,7aS)-3a-Hydroxymethyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol (210897-76-0) → C20H25BrO4 (441352-72-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / MnO₂ / CH₂Cl₂ / 20 °C

2: 80 percent / NaOH / Bu₄NHSO₄ / benzene

3: H₂O₂; NaOH / methanol / 20 °C

4: LiAlH₄ / dioxane / Heating

5: 86 percent / NBS / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; methanol; dichloromethane; benzene;

DOI:10.1016/S0040-4039(02)00750-5

upstream raw materials:

C₁₈H₂₁BrO₃

6,7-epoxy-1,4,4a,6,7,8a-hexahydro-1,4-methano-naphthalene-5,8-dione

ethyl 5-oxo-tricyclo[5.2.1.0.]deca-3,8-diene-2-carboxylate

(1R,3aS,4S,7R,7aS)-3a-Hydroxymethyl-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol

Downstream raw materials:

2-((1R,5R)-1-Benzyloxymethyl-5-methoxymethoxy-cyclopent-2-enyl)-ethanol

2-(1-benzyloxymethyl-5-methoxymethoxy-cyclopent-2-enyl)-N,N-dimethyl-acetamide

(1R,3R,3aR,4S,7R,7aS)-3a-Benzyloxymethyl-3-methoxymethoxy-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-1-ol